Figure 4

Effect of iguratimod (IGU) on the levels of apoptosis-related proteins (Bcl-2, Caspase-3 and Bax) in non-obese diabetic (NOD) mice (A). Model vs. normal, #p < 0.05, ##p < 0.01. IGU 10 mg/kg and IGU 30 mg/kg vs. model, *p < 0.05, **p < 0.01. IGU 30 mg/kg vs. IGU 10 mg/kg, △p < 0.05, △△p < 0.01. Western blotting analysis was utilized to evaluate the expression levels of apoptosis-associated proteins (B). Effect of iguratimod (IGU) on apoptosis in submandibular gland epithelial cells in non-obese diabetic (NOD) mice (C,D).