Figure 5

In-silico generation of a seven-pool human brain Z-spectrum data, acquired with a Sinc-Gaussian saturation pulse train, using an application optimized NN. (a) A representative brain CEST signal generated using the NN-predicted (blue) or the reference standard method (black). (b) Statistical analysis of the entire test set data, demonstrating an excellent agreement between the NN-predicted and ground truth reference values (Pearson’s r > 0.99, p < 0.0001, normalized root mean square error = 0.0003).