Figure 4

Immune landscape of NETs-high and NETs-low subtypes. (A) Violin plots show the median, and quartile estimations for each immune score, stromal score,ESTIMATE score, and tumor purity score. (B) Relative proportion of immune infifiltration in NETs-high and NETs-low subtypes. (C) Correlation analysis of each infifiltrating immune cells in the colon cancer; (D) Violin plot visualizes signifificantly different immune cells between different subtypes; Box plots present differential expression of multiple immune checkpoints (E), and HLA genes (F) between NETs-high and NETs-low subtypes. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001.