Figure 2
Comparison of protein expression at 3 months old and 24 months old. (A, B) Volcano plots comparing protein expression at 3 months old and 24 months old in cortex and hippocampus, respectively. Welch’s t-tests were performed to identify significantly changed proteins (N = 6). The proteins with q-value < 0.05 are highlighted with color. Volcano plots comparing 3 months old and 15 months old, and 15 months old and 24 months old are shown in Figure S1. (C, D) Overlaps of significantly upregulated (C) and downregulated proteins (D) between cortex and hippocampus, among the commonly identified proteins in these tissues. (E, F) GO term (“molecular function” and “biological process”) enrichment analysis for significantly upregulated (blue) and downregulated proteins (orange) in cortex (E) and hippocampus (F). The top 5 terms are shown. No terms were significantly enriched for the downregulated proteins in hippocampus.
