Table 2 Basal characteristics of study population.

From: Serum exosomal microRNA-1258 may as a novel biomarker for the diagnosis of acute exacerbations of chronic obstructive pulmonary disease

 

NC (N = 45)

SCOPD (N = 42)

AECOPD (N = 66)

p value

NC VS SCOPD

p value

NC VS AECOPD

p value

SCOPD

VS AECOPD

Age (years)

75.9 ± 2.66

78.4 ± 10.11

77.1 ± 9.12

0.758

0.802

0.889

Sex n (%)

      

Male

22 (48.9)

30 (71.4)

58 (87.9)

0.052

 < 0.001

0.047

Female

23 (51.1)

12 (28.6)

8 (12.1)

WBC (× 109)

5.96 ± 1.31

6.49 ± 2.48

7.86 ± 3.52

0.215

 < 0.001

0.010

NEU (× 109/L)

3.53 ± 1.03

4.19 ± 1.68

6.34 ± 3.42

0.032

 < 0.001

 < 0.001

NLR

2.12 ± 0.386

3.29 ± 2.71

9.25 ± 13.39

0.009

 < 0.001

 < 0.001

EO (× 109/L)

0.13 ± 0.103

0.222 ± 0.529

0.15 ± 0.175

0.259

0.535

0.295

CRP (mg/dl)

0.46 ± 0.35

1.17 ± 1.23

3.15 ± 4.34

 < 0.001

 < 0.001

 < 0.001

PCT (μg/L)

0.068 ± 0.046

0.108 ± 0.139

0.20 ± 0.343

0.071

0.003

0.016

LDH (U/L)

153.6 ± 16.55

208.8 ± 67.5

196.9 ± 44.8

 < 0.001

 < 0.001

0.422

 

SCOPD(%)

AECOPD(%)

p value

   

Comorbidities and complications

      

 Respiratory failure

1 (0.03)

36 (0.61)

 < 0.001

   

 Chronic pulmonary heart disease

0 (0)

9 (0.15)

0.05

   

 Autoimmune disease

1 (0.03)

2 (0.03)

1.00

   

 Cardiovascular disease

13 (0.41)

33 (0.56)

0.163

   

 Endocrine metabolic disease

4 (0.13)

17 (0.29)

0.078

   

 Cerebrovascular disease

1 (0.03)

14 (0.24)

0.011

   

 Neuropsychological disease

3 (0.09)

8 (0.14)

0.804

   

 Chronic nephrosis

2 (0.06)

8 (0.14)

0.476

   

 Chronic liver disease

0 (0)

4 (0.07)

0.332

   

 Chronic gastric disease

0 (0)

4 (0.07)

0.332

   
  1. WBC White blood cells, NEU Neutrophil, NLR Neutrophil to lymphocyte ratio, EO Eosinophil, CRP C-reaction protein, PCT Procalcitonin, LDH Lactate dehydrogenase.
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