Table 4 Results of CHO-K1/HPRT mutation assay with activation expressed as average values of three replicates (plates) ± sample standard deviations.

From: Toxicological investigation of lilial

sample

Without S9

With S9

NMC

PE (%)

MF (/106)

NMC

PE (%)

MF (/106)

NC

2 ± 1

66 ± 8

18 ± 9

–

–

–

VC

0 ± 0

69 ± 6

0 ± 0

2 ± 2

59 ± 2

17 ± 17

PC: 3MC

3 ± 4

66 ± 3

25 ± 31

17 ± 2

55 ± 4

152 ± 14***

lilial 500 µM

0

0

NA

1 ± 1

56 ± 3

6 ± 5

  1. VC vehicle control, NC negative control, PC positive control, NMC number of mutant colonies, PE plating efficiency, MF mutation frequency, 3MC 3-methylcholanthren. Statistical significance was verified by ANOVA followed by Tukey test (*p ˂ 0.05, **p ˂ 0.01, ***p˂ 0.001).
  2. Significant values are in [bold]
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