Table 7 Relative fold gene expression of hTERT-immortalized epithelial proximal tubular cells (RPTEC/TERT1) treated with 100 µM lilial or its metabolically activated form (lilial with S9).

From: Toxicological investigation of lilial

Gene

Lilial

Lilial with S9

Vehicle control

Tetracycline

Fold

SD

Fold

SD

Fold

SD

Fold

SD

HMOX

1.19

0.50

0.94

0.05

1.02

0.02

4.93**

0.38

TIMP1

0.33*

0.11

0.86

0.01

1.16

0.12

1.31

0.04

IPO8

0.95

0.41

0.96

0.02

1.02

0.02

1.41**

0.02

IL6

1.09

0.43

1.21*

0.03

1.03

0.03

1.70

1.30

CST3

0.33*

0.10

0.78*

0.00

1.06

0.06

1.64*

0.10

IL8

0.59

0.19

0.94

0.02

1.14

0.11

1.19

0.02

CLU

1.10

0.37

1.05

0.09

1.10

0.09

4.09*

0.39

  1. DMSO was used as a vehicle control in the same concentration as in samples.
  2. Tetracycline (100 µM) was used as positive control known for its nephrotoxicity.
  3. Significant values are in [bold].
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