Figure 1
Manhattan plot of P-values generated using logistic regression analysis in the European ancestry sample (n = 14,620). An additive model was used to assess the disease susceptibility impact of the minor (coded) allele at each position, while controlling for age, BMI, sex, ancestry, nursing home status, chemotherapy, diabetes, HIV, transplant medications, corticosteroids, and medium or high-risk antibiotic exposure as covariates. Genomic coordinates are displayed along the X-axis, and the negative logarithm of logistic regression P-values are displayed on the Y-axis. Each dot represents a SNV in the regression model, with associated P-values plotted accordingly, while the triangle represents the most significantly associated SNV. The dotted line represents the negative logarithm of the genome-wide significance threshold (P < 5 × 10–8). Colors are used to distinguish between SNVs in adjacent chromosomes.
