Figure 3 | Scientific Reports

Figure 3

From: Novel, clinically relevant genomic patterns identified by comprehensive genomic profiling in ATRX-deficient IDH-wildtype adult high-grade gliomas

Figure 3

Oligodendroglioma-like morphology of case #17 shown by the H&E-stained sections from the (a) primary and (b) recurrent tumor resected following radio-chemotherapy (scale bar: 50 μm). (c and d) ATRX expression was lost in both samples. (e) MLH1 and (g) PMS2 were retained in the primary specimen, while both (f) MLH1 and (h) PMS2 were lost in the recurrent tumor. (i) NTRK2 fluorescent in situ hybridization showed break apart signals (white arrowheads) in the tumor cells validating the presence of NTRK2::LRRFIP2 and LRRFIP2::NTRK2 fusions revealed by next-generation sequencing (j).

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