Figure 1 | Scientific Reports

Figure 1

From: Orange juice containing Pediococcus acidilactici CE51 modulates the intestinal microbiota and reduces induced inflammation in a murine model of colitis

Figure 1

Experimental design. The experiment was carried out with 45 animals divided in 5 experimental groups Control (C); Colitis (CL); Colitis + Probiotic (CLPR; Colitis + Placebo (CLP); Colitis + Sulfasalazine (CLS) for 37 days divided in the following stages: Adaptation period of 7 days (Blue line); T0/d0: Initiation of administration of probiotic orange juice containing P. acidilactici CE51 for the CLPR group, or orange juice (placebo) for the CLP group, which lasted until the last day of the experiment (Green line); T1/d09: Beginning of the period of induction of ulcerative colitis by DSS, which lasted 6 consecutive days (Yellow line); T2/d15: The arrow indicates the withdrawal of the DSS and the beginning of the treatments that lasted 5 and 15 days. In this period also started treatment with sulfasalazine (Orange line); T3/d20: Exact time when the first euthanasia occurred (Euthanasia 1) after treatment with probiotic orange juice, placebo or sulfasalazine for 5 days; T4/d30: Exact time when the second euthanasia (Euthanasia 2) occurred after treatment with probiotic orange juice, placebo or sulfasalazine for 15 days. d Day (Above the colored lines); T Time (Below the colored lines); Black arrow Induction of ulcerative colitis by DSS.

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