Table 1 Patient demographics for placentas from singleton pregnancies used for placenta perfusion to collect STBEVs. Data is presented as median values (min–max) for each group.

From: Preliminary evidence that blocking the uptake of placenta-derived preeclamptic extracellular vesicles protects the vascular endothelium and prevents vasoconstriction

 

Normal (n = 13)

PE pregnancies

PE total (n = 12)a

EOPE (n = 4)

LOPE (n = 8)

Maternal age (years)

36 (31–41)

31.5 (23–44)

29.5 (28–38)

32 (23–44)

GA (weeks + days)

39 + 1 (38 + 1–41 + 4)

35 + 1 **** (27 + 1–39 + 2)

28 + 4 ***/**b (27 + 1–30 + 0)

36 + 2 *** (34 + 0–39 + 2)

Max sys BP (mmHg)

125 (90–156)

167 **** (142–200)

179 **/– (150–195)

162 **** (142–200)

Max dia BP (mmHg)

75 (50–92)

103 **** (92–122)

116 ***/* (110–122)

100 **** (92–121)

Fetal weight (g)

3990 (3110–4375)

2079 **** (760–3500)

960 ***/** (760–1200)

2352 *** (1710–3500)

  1. aThe PE group is a mix of EOPE (n = 4) and LOPE (n = 8). BP = blood pressure; dia = diastolic; EOPE = early-onset PE; GA = gestational age; LOPE = late-onset PE; PE = preeclampsia; sys = systolic. Mann–Whitney test, comparing Normal with PE, EOPE or LOPE, and bEOPE with LOPE: *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
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