Figure 2 | Scientific Reports

Figure 2

From: Immune inhibitory receptor-mediated immune response, metabolic adaptation, and clinical characterization in patients with COVID-19

Figure 2The alternative text for this image may have been generated using AI.

IR patterns mediated by 42 inhibitory receptors and clinical characteristics of each pattern. (A) Expression levels of 42 IR genes between two IR clusters in the training cohort (Mann–Whitney U test). The upper and lower ends of the boxes represent the interquartile range of values. The lines in the boxes represent median values, and the dots show outliers. (B) Differences in the hospital-free days at day 45 (HFD-45) between the two IR clusters in the training cohort (Mann–Whitney U test). (C–F) Differences in the concentrations of D-dimer (C), CRP (D), lactate (E), and ferritin (F) between the two IR clusters in the training cohort (Mann–Whitney U test). (G) Differences in the SOFA scores between the two IR clusters in the training cohort (unpaired t-test). (H–J) Differences in the proportions of ICU (H), mechanical ventilation (I), and Charlson score > 6 (J) between the two IR clusters in the training cohort (chi-square test). Asterisks represent the statistical P value (*P < 0.05; **P < 0.01; ***P < 0.001; ns no significance).

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