Figure 6 | Scientific Reports

Figure 6

From: Immune inhibitory receptor-mediated immune response, metabolic adaptation, and clinical characterization in patients with COVID-19

Figure 6The alternative text for this image may have been generated using AI.

Prognostic value of IRscore for the severity of COVID-19 in test cohorts. (A) Alluvial diagram showing changes in IR_cluster, gene cluster, and IRscore. (B) The performance (sensitivity and specificity) of the IRscore on predicting the mechanical ventilator support state of patients with COVID-19 was evaluated by ROC curves. The 7-, 14-, and 26-day ROC curves of the model in the training cohort. (C) The HFD-45 between patients with high and low IRscores in the test cohort (Mann–Whitney U test). (D–F) Concentrations of ferritin (D, unpaired t test), procalcitonin (E, Mann–Whitney U test), and CRP (F, unpaired t test) between patients with high and low IRscores in the test cohort. (G) IRscores between ICU and non-ICU patients in the test cohort (Mann–Whitney U test). (H) IRscore of patients with or without mechanical ventilation in the test cohort (Mann–Whitney U test). (I) The performance (sensitivity and specificity) of the IRscore in predicting the mechanical ventilator support state of patients with COVID-19 was evaluated by ROC curves. The 7-, 14-, and 26-day ROC curves of the model in the testing cohort. Asterisks represent the statistical P value (*P < 0.05; **P < 0.01; ***P < 0.001; ns no significance). MV mechanical ventilation.

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