Table 2 Associations between clinicopathological variables in METABRIC and immune cell clusters.
From: Machine learning-based cluster analysis of immune cell subtypes and breast cancer survival
Clinicopathological variable | Immune cell subtype clusters | p value* | ||
|---|---|---|---|---|
Cluster A, n = 1113 (83.2%) | Cluster B, n = 224 (16.8%) | Total n = 1337 | ||
Mean age (SD) | 59.4 (13.1) | 59.8 (13.2) | 59.4 (13.1) | 0.67 |
Age group | Â | Â | Â | 0.91 |
 < 60 years | 556 (50.0) | 111 (49.6) | 667 (49.9) |  |
 ≥ 60 years | 557 (50.0) | 113 (50.4) | 670 (50.1) |  |
Stage | Â | Â | Â | 0.41 |
 0 | 2 (0.2) | 1 (0.6) | 3 (0.3) |  |
 1 | 2781 (33.5) | 56 (32.2) | 334 (33.2) |  |
 2 | 464 (55.8) | 105 (60.3) | 569 (56.6) |  |
 3 | 80 (9.6) | 12 (6.9) | 92 (9.2) |  |
 4 | 7 (0.8) | 7 (0.7) | 0 |  |
Grade | Â | Â | Â | 0.11 |
 1 | 89 (8.3) | 13 (6.0) | 102 (7.9) |  |
 2 | 405 (37.7) | 70 (32.4) | 475 (36.8) |  |
 3 | 580 (54.0) | 133 (61.6) | 713 (55.3) |  |
Histology | Â | Â | Â | 0.006 |
 Ductal | 830 (75.1) | 191 (86.0) | 1021 (76.9) |  |
 Lobular | 96 (8.7) | 10 (4.5) | 106 (8.0) |  |
 Mixed | 128 (11.6) | 16 (7.2) | 144 (10.9) |  |
 Others | 51 (4.6) | 5 (2.3) | 56 (4.2) |  |
ER | Â | Â | Â | 0.006 |
 Positive | 799 (71.8) | 140 (62.5) | 939 (70.2) |  |
 Negative | 314 (28.2) | 84 (37.5) | 398 (29.8) |  |
PR | Â | Â | Â | 0.16 |
 Positive | 529 (47.5) | 95 (42.4) | 624 (46.7) |  |
 Negative | 584 (52.5) | 129 (57.6) | 713 (53.3) |  |
HER2 | Â | Â | Â | 0.24 |
 Positive | 168(15.1) | 27(12.1) | 195(14.6) |  |
 Negative | 945(84.9) | 197(87.9) | 1,142(85.6) |  |
Relapse | Â | Â | Â | 0.003 |
 No | 677(60.9) | 112(50.0) | 789(59.1) |  |
 Yes | 435(39.1) | 112(50.0) | 547(40.9) |  |
Death | Â | Â | Â | 0.001 |
 No | 522(46.9) | 78(34.8) | 600(44.9) |  |
 Yes | 591(53.1) | 146(65.2) | 737(55.1) |  |
Cytolytic activity |  |  |  | < 0.0001 |
 CYT score | 6.9 (0.7) | 6.3 (0.6) | 6.8 (0.8) |  |
