Figure 1 | Scientific Reports

Figure 1

From: A Kinase Interacting Protein 1 regulates mitochondrial protein levels in energy metabolism and promotes mitochondrial turnover after exercise

Figure 1

Mitochondrial function and integrity: mitochondrial state 3, state uncoupled and state 4 respiratory capacity. Shown are (A) state 3 respiration with pyruvate and malate (PyrMal) in nanomole per minute per milligram of mitochondrial protein (nmol/min/mg mito protein) (N = 7/group), (B) state uncoupled respiration with PyrMal in nmol/min/mg mito protein (N = 4–7/group), (C) state 4 respiration for PyrMal in nmol/min/mg mito protein (N = 7/group), (D) state 3 respiration for palmitoyl carnitine and malate (PCarnMal) substrates in nmol/min/mg mito protein (N = 7/group), (E) state uncoupled respiration with PCarnMal in nmol/min/mg mito protein (N = 7/group), (F) state 4 respiration for PCarnMal in nmol/min/mg mito protein (N = 7/group). WT, wild type mice; AKIP1-TG, AKIP1 transgenic mice. Graphs represent mean ± standard error of the mean (SEM). Statistical analysis for comparing two groups was performed with Student’s t-test or Mann–Whitney U test. < 0.05 was considered statistically significant; p** < 0.01.

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