Figure 6 | Scientific Reports

Figure 6

From: A Kinase Interacting Protein 1 regulates mitochondrial protein levels in energy metabolism and promotes mitochondrial turnover after exercise

Figure 6

Graphical abstract: mitochondrial alterations with AKIP1 overexpression. Baseline mitochondrial changes in AKIP1-TG mice are depicted, included a reduction in mitochondrial respiratory capacity for fatty acids and decrements in protein levels of mitochondrial proteins involved in energy metabolism. Upon exercise, a subsequent set of mitochondrial changes occur in AKIP1-TG mice. As in sedentary mice, fatty acid oxidation is decreased, but now also respiratory capacity for glucose substrates is decreased. These changes were accompanied by association with changes in markers for mitochondrial fission and mitophagy, suggesting enhanced mitochondrial turnover with exercise and AKIP1 overexpression. AKIP1-TG, AKIP1 transgenic mice; FA’s, fatty acids.

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