Figure 3 | Scientific Reports

Figure 3

From: XBB.1.5 spike protein COVID-19 vaccine induces broadly neutralizing and cellular immune responses against EG.5.1 and emerging XBB variants

Figure 3

Humoral Responses Following XBB.1.5 Booster in Rhesus Macaques. Pseudovirus neutralization titers in rhesus macaques boosted with XBB.1.5 approximately 8 months after Prototype rS (top graph) or bivalent (Prototype + BA.5; bottom graph) priming regimens as shown in the study design diagram. Note that all immunizations were administered with 50 µg Matrix-M adjuvant. Sera were collected five weeks before the boost (Day 210) and two weeks after the booster dose (Day 260). Statistically significant differences in post-boost titers between the two groups after are marked with asterisks above the group with the higher titers: *P < 0.05; **P < 0.01. Open circles represent individual data points, solid bars represent group geometric mean titers, error bars represent 95% confidence intervals, and the horizontal dashed line represents the assay limit of detection.

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