Figure 4 | Scientific Reports

Figure 4

From: XBB.1.5 spike protein COVID-19 vaccine induces broadly neutralizing and cellular immune responses against EG.5.1 and emerging XBB variants

Figure 4

CD4 + T Cell Responses to an XBB.1.5 Booster. (a) CD4 + T cell responses in mice primed with two doses of Prototype or bivalent (Prototype + BA.5) rS and boosted with XBB.1.5 rS as outlined in Fig. 2. Splenocytes were collected two weeks after the booster dose. (b) CD4 + T cell responses in rhesus macaques primed with bivalent (Prototype + BA.5) rS and boosted with XBB.1.5 rS. Peripheral blood mononuclear cells (PBMCs) were collected 2 weeks after the booster dose. Open circles represent individual animal data points, solid bars represent group geometric mean values with 95% CI error bars.

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