Table 4 The first fifteen enriched GO terms (lowest adjusted p-value by Bonferroni correction) resulted from the ClueGO algorithm for differentially methylated genes during early response, mid response, and whole period.
From: Genome-wide epigenetic modifications in sports horses during training as an adaptation phenomenon
Time frame | ClueGO enriched term | Corrected p-value | Nr. genes |
|---|---|---|---|
Early response | Protein maturation | 0.00047 | 7 |
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 0.00828 | 3 | |
Neutral lipid metabolic process | 0.00828 | 3 | |
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | 0.01183 | 3 | |
Acylglycerol metabolic process | 0.01626 | 3 | |
Negative regulation of binding | 0.01718 | 4 | |
Negative regulation of binding | 0.01718 | 4 | |
Specification of symmetry | 0.02349 | 3 | |
Negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 0.02349 | 3 | |
Cargo receptor activity | 0.02544 | 3 | |
Amyloid fibril formation | 0.02884 | 3 | |
Camera-type eye morphogenesis | 0.02906 | 3 | |
Regulation of BMP signaling pathway | 0.02971 | 3 | |
Activation of cysteine-type endopeptidase activity involved in apoptotic process | 0.02999 | 3 | |
Maintenance of protein location | 0.02999 | 3 | |
Mid response | Regulation of cation transmembrane transport | 0.00394 | 13 |
Lytic vacuole membrane | 0.00519 | 13 | |
Lysosomal membrane | 0.00519 | 13 | |
Regulation of ion transmembrane transport | 0.01568 | 14 | |
Vacuolar membrane | 0.01767 | 13 | |
Regulation of ion transmembrane transporter activity | 0.02176 | 10 | |
Regulation of transmembrane transporter activity | 0.03096 | 10 | |
Anterograde trans-synaptic signaling | 0.03113 | 17 | |
Chemical synaptic transmission | 0.03113 | 17 | |
Trans-synaptic signaling | 0.03600 | 17 | |
Extrinsic component of cytoplasmic side of plasma membrane | 0.04077 | 6 | |
Dendritic spine | 0.04541 | 8 | |
Synaptic signaling | 0.04750 | 17 | |
Regulation of transporter activity | 0.04772 | 10 | |
Regulation of ion transport | 0.04875 | 16 | |
Whole period | Regulation of blood circulation | 0.00004 | 22 |
Regulation of heart contraction | 0.00006 | 19 | |
Cardiac conduction | 0.00008 | 14 | |
Neuron projection guidance | 0.00009 | 21 | |
Wnt signaling pathway | 0.00035 | 28 | |
Lysosomal membrane | 0.00042 | 23 | |
Modulation of chemical synaptic transmission | 0.00054 | 24 | |
Vacuolar membrane | 0.00058 | 24 | |
Epithelial cell migration | 0.00058 | 19 | |
Regulation of epithelial cell migration | 0.00062 | 16 | |
Transmembrane transporter complex | 0.00086 | 19 | |
Regulation of cation transmembrane transport | 0.00101 | 21 | |
Synapse organization | 0.00102 | 23 | |
Dendritic spine | 0.00103 | 14 | |
Calcium channel complex | 0.00115 | 8 |
