Figure 6
Neuroprotection mediated by IRAP inhibition was independent of changes in blood pressure, vascular reactivity and vascular density. (A) Systolic blood pressure determined pre stroke and at 70 h post stroke was not different between sham operated, vehicle and HFI419 (1 nmol) treated animals. (B) Myograph preparations of the SHR basilar artery indicated no change in vascular reactivity in response to increasing concentrations of HFI419 (n = 3–5; data represented by mean ± SEM). Comparison of GLUT1 immunopositively stained cell area within the striatal core (C), cortical core (D) and cortical penumbra (E) revealed no differences with either stroke or treatment with an IRAP inhibitor (n = 4–9, data represented by mean ± SEM).
