Table 4 Univariable and multivariable cox regression analysis to predict survival in gastric cancer patients with brain metastasis.

Age

 Less than 60 years

1 [ref]

–

1 [ref]

–

 Greater than 60 years

0.978 (0.786–1.218)

0.843

0.954 (0.761–1.196)

0.684

Gender

 Female

1 [reference]

–

1 [reference]

–

 Male

0.929 (0.731–1.182)

0.550

0.975 (0.758–1.253)

0.842

Race

 Caucasian

1 [reference]

–

1 [reference]

–

 African American

1.346 (0.897–2.020)

0.151

1.195 (0.771–1.852)

0.426

 Other

0.997 (0.703–1.413)

0.986

0.964 (0.670–1.386)

0.843

Bone

1.363 (1.084–1.714)

0.008

1.255 (0.994–1.586)

0.057

1.404 (1.109–1.776)

0.005

1.304 (1.025–1.659)

0.031

Liver

1.108 (0.888–1.382)

0.364

1.082 (0.861–1.361)

0.499

Lung

1.103 (0.881–1.383)

0.393

1.128 (0.894–1.423)

0.311

Surgery

0.452 (0.273–0.748)

0.002

0.452 (0.269–0.758)

0.003

0.454 (0.270–0.765)

0.003

0.458 (0.268–0.781)

0.004

Grade

 Grade-I

1 [reference]

–

1 [reference]

–

1 [reference]

–

1 [reference]

–

 Grade-II

2.143 (0.522–8.797)

0.290

2.274 (0.551–9.389)

0.256

1.970 (0.479–8.106)

0.340

2.071 (0.5–8.574)

0.315

 Grade-III

3.925 (0.969–15.901)

0.055

3.452 (0.843–14.129)

0.085

3.728 (0.920–15.112)

0.657

3.324 (0.811–13.620)

0.095

 Grade-IV

5.799 (1.224–27.470)

0.027

5.322 (1.114–25.415)

0.036

5.774 (1.219–27.358)

0.027

5.287 (1.106–25.268)

0.037

 Unknown

3.661 (0.901–14.872)

0.070

2.869 (0.696–11.832)

0.145

3.352 (0.824–12.633)

0.091

2.717 (0.658–11.226)

0.167

Histology

 Other

1 [reference]

–

1 [reference]

–

 Adenocarcinoma

0.786 (0.537–1.150)

0.215

0.800 (0.540–1.186)

0.266

 Mucinous

0.789 (0.188 – 3.306)

0.746

0.846 (0.201–3.555)

0.819

 Papillary

0.189 (0.026–1.394)

0.102

0.215 (0.029–1.588)

0.132

 Signet ring cell

1.155 (0.743–1.794)

0.522

1.136 (0.719)–1.796)

0.584

Site

 Cardia

1 [reference]

–

1 [reference]

–

1 [reference]

–

1 [reference]

–

 Antrum

1.845 (1.084–3.139)

0.024

1.957 (1.122–3.414)

0.018

1.784 (1.029–3.091)

0.039

1.858 (1.045–3.302)

0.035

 Body

1.760 (1.100–2.814)

0.018

1.477 (0.910–2.398)

0.114

1.724 (1.065–2.790)

0.027

1.431 (0.871–2.350)

0.157

 Fundus

1.429 (0.852–2.399)

0.176

1.279 (0.752–2.174)

0.363

1.384 (0.811–3.262)

0.233

1.229 (0.712–2.214)

0.459

 Greater

2.479 (1.337–4.596)

0.004

2.339 (1.238–4.422)

0.009

2.093 (1.602–4.124)

0.033

1.963 (0.978–3.9410

0.058

 Lesser

1.375 (0.809–2.338)

0.240

1.142 (0.657–1.984)

0.638

1.356 (0.783–2.346)

0.277

1.102 90.623–1.950)

0.738

 Pylorus

0.873 (0.216–3.532)

0.849

1.122 (0.272–4.638)

0.873

0.915 (0.226–3.702)

0.900

1.248 (0.301–5.173)

0.760

 Not specified

1.516 (1.171–1.962)

0.002

1.213 (0.898–1.639)

0.208

1.441 (1.103–1.883)

0.007

1.151 (0.843–1.571)

0.368

N

 No

1 [reference]

–

1 [reference]

–

1 [reference]

–

1 [reference]

–

 N1

1.223 (0.924–1.617)

0.159

1.203 (0.904–1.601)

0.205

1.267 (0.950–1.690)

0.108

1.243 (0.926–1.669)

0.148

 N2

0.971 (0.507–1.861)

0.930

1.041 (0.529–2.047)

0.908

1.051 (0.547–2.020)

0.880

1.144 (0.579–2.260)

0.699

 N3

1.354 (0.860–2.130)

0.190

1.392 (0.877–2.208)

0.160

1.398 (0.878–2.225)

0.158

1.424 (0.886–2.287)

0.144

 Unknown

1.518 (1.148–2.008)

0.003

1.372 (1.026–1.834)

0.033

1.506 (1.126–2.016)

0.006

1.390 (1.027–1.881)

0.033

T stage

 T1

1 [reference]

–

1 [reference]

–

 T2

1.468 (0.777–2.771)

0.237

1.517 (0.801–2.873)

0.201

 T3

0.923 (0.594–1.436)

0.723

0.909 (0.577–1.430)

0.679

 T4

1.5 (0.968–2.323)

0.069

1.380 (0.874–2.179)

0.167

 Others

1.227 (0.892–1.687)

0.209

1.198 (0.864–1.660)

0.279

Tumor size

 ≤ 5 cm

1 (reference)

–

1 (reference)

–

 > 5 cm

0.993 (0.671–1.470)

0.973

0.982 (0.654–1.473)

0.982

 Others

1.148 (0.878–1.500)

0.314

1.145 (0.869–1.510)

0.336