Table 4 PS, PDI, ZP and drug retention % of FST-loaded LPHNPs aqueous dispersions (F3) stored at refrigerated (4 ± 1 °C) and ambient conditions (See Table 1 for F3 composition). Each value represents the ± SD (n = 3). * Significant at p < 0.05 monthly vs. initial, ** Highly significant at p < 0.01 monthly vs. initial, *** Extremely significant at p < 0.001 monthly vs. initial, ### Extremely significant at p < 0.001 refrigerated temperature vs. ambient temperature after 6 months.

From: Formulation of lipid polymer hybrid nanoparticles of the phytochemical Fisetin and its in vivo assessment against severe acute pancreatitis

Storage time

Evaluation parameters

Refrigerated temperature (4 ± 1 °C)

Ambient temperature

PS (nm)

PDI

ZP (mV)

Drug retention (%)

PS (nm)

PDI

ZP (mV)

Drug retention (%)

Zero time

125.39 ± 0.924

0.357 ± 0.012

 + 30.16 ± 1.418

100.00 ± 0.000

125.39 ± 0.924

0.357 ± 0.012

 + 30.16 ± 1.41

100.00 ± 0.000

1 month

119.42 ± 0.716

0.351 ± 0.014

 + 29.82 ± 1.722

99.72 ± 4.573

137.19 ± 2.709

0.382 ± 0.078

 + 25.56 ± 3.006

92.07 ± 1.226

2 month

118.67 ± 2.082

0.334 ± 0.028

 + 30.09 ± 2.610

94.34 ± 0.566

147.05 ± 0.172***

0.359 ± 0.055

 + 22.51 ± 2.789**

86.33 ± 8.572

3 month

121.33 ± 2.041

0.311 ± 0.005

 + 28.67 ± 3.396

93.05 ± 2.218

184.16 ± 4.092***

0.588 ± 0.132**

 + 20.99 ± 0.985***

84.44 ± 2.673

4 month

117.33 ± 3.451

0.412 ± 0.004

 + 28.54 ± 1.592

92.86 ± 4.962

205.75 ± 4.549***

0.608 ± 0.084***

 + 20.27 ± 0.231***

74.63 ± 6.302*

5 month

123.05 ± 3.595

0.342 ± 0.0.03

 + 30.29 ± 1.041

92.11 ± 0.247

223.00 ± 2.564***

0.673 ± 0.071***

 + 18.35 ± 2.394***

72.59 ± 5.711**

6 month

120.95 ± 1.624###

0.366 ± 0.038###

 + 29.96 ± 0.613###

90.42 ± 4.892###

239.45 ± 3.743***

0.733 ± 0.044***

 + 14.04 ± 1.977***

67.81 ± 4.267**

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