Figure 4

Boxplot distributions of the percentage change between the total number of drugs with disproportionally reported adverse events (AEs) before the Coronavirus disease 2019 (COVID-19) pandemic up to 31/Dec/2019 and up to 31/Dec/2021 by using all reports (orange), on one side, and excluding entries solely registering COVID-19 vaccines (blue), on the other side, for the total number of 919 AEs considered in this study (left) and the 25 AEs most impacted by the COVID-19 pandemic (right).