Figure 1
From: SIGNET: transcriptome-wide causal inference for gene regulatory networks
SIGNET workflow for gene regulatory network (GRN) construction. SIGNET takes four steps to conduct causal inference and construct a GRN from transcriptomic and genotypic data: 1. Preprocessing transcriptomic and genotypic data to ensure data quality; 2. Identifying genotypic instrumental variables; 3. Constructing a transcriptome-wide GRN via causal inference; 4. Visualizing subnetworks of the GRN and validating with public databases.
