Figure 7
Expression levels and methylation ratios of sarcomere component proteins and enzymes of BCAA degradation. (a) Component proteins of the sarcomere, including enzymes involved in providing energy for contraction, are presented with a diagram of the sarcomere. (b) Enzymes of BCAA degradation. Bcat1 was not detected at the protein or transcript level. BCKA: branched-chain keto acid. #represents proteins that are hypermethylated in both liver and muscle but differ significantly between the liver and skeletal muscle in both methylation and protein expression. See Fig. 5 for detailed key to plots of expression levels versus methylation ratios for encoding genes. A representative pattern for skeletal muscle-dominant DM-DEPs is provided.
