Figure 1 | Scientific Reports

Figure 1

From: A gut microbial metabolite of linoleic acid ameliorates liver fibrosis by inhibiting TGF-β signaling in hepatic stellate cells

Figure 1

Effects of pioglitazone on the amount of LA metabolites in adipose tissue and on the gut microbiota in KK-Ay mice. (A) Concentrations of LA metabolites in epididymal adipose tissue of control mice or mice treated with pioglitazone (Pio) for 4 weeks. HYA + HYC; sum of the amounts of HYA and HYC. Data are shown for seven mice of each group, with the horizontal bar indicating the mean. *p < 0.05, **p < 0.01, ***p < 0.001 versus control mice (Student’s t test). (B) Gut microbiota profile at the genus level for feces of control mice or mice treated with pioglitazone for 3 weeks as determined by 16S rRNA gene analysis. Only bacteria that account for > 5% of the total are shown. Data are presented for seven mice of each group.

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