Figure 2 | Scientific Reports

Figure 2

From: Protective role of CXCR7 activation in neonatal hyperoxia-induced systemic vascular remodeling and cardiovascular dysfunction in juvenile rats

Figure 2

Effects of CXCR7 activation on neonatal hyperoxia induced systemic vascular stiffness and cardiac function in juvenile rats. (A) Doppler ultrasound shows that neonatal hyperoxia exposure increased vascular stiffness in juvenile rats, but there was no difference in PWV between the room air treated and hyperoxia treated TC14012 groups. Echocardiography shows that TC14012 administration preserved long-term LV function parameters (B) Stroke Volume (C) Ejection Fraction (D) Fractional Shortening (E) Cardiac Output (F) Left ventricular End Systolic Volume in the hyperoxia-exposed rats. n = 6–9/group, data are mean ± SEM, Two-way ANOVA with Tukey’s multiple comparisons test. *p < 0.05, **p < 0.01, ****p < 0.0001; RA + PL = room air-exposed placebo treated versus HYP + PL = hyperoxia-exposed placebo treated versus RA + TC14012 = room air treated with TC14012 versus HYP + TC14012 = hyperoxia-exposed treated with TC 14012.

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