Figure 6 | Scientific Reports

Figure 6

From: Protective role of CXCR7 activation in neonatal hyperoxia-induced systemic vascular remodeling and cardiovascular dysfunction in juvenile rats

Figure 6

CXCR7 decreases proinflammatory response in hyperoxia-exposed HCAECs. Treatment with TC14012 of hyperoxia-exposed HCAECs reduced the gene expression of (A) NLRP1 (B) MCP-1 (C) NF-кB1 (D) TGF-β1 (E) MMP1 (F) LOX (G) SDF-1. n = 3/group, data are mean ± SEM, Two-way ANOVA with Tukey’s multiple comparisons test. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001; RA = normoxia versus HYP = hyperoxia versus RA + TC14012 = normoxia treated with TC14012 versus HYP +TC14012 = hyperoxia-exposed treated with TC14012; all experiments were performed in triplicate.

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