Table 2 Clinical characteristics of the study population of 120 patients diagnosed with childhood-onset, adamantinomatous craniopharyngioma (CP) and recruited in the studies KRANIOPHARYNGEOM 2000/2007 between 2000 and 2019 with or without visual impairment at diagnosis.
From: Vision-related quality of life in patients with childhood-onset craniopharyngioma
Characteristics | Overall | Visual impairment at dgx | No visual impairment at dgx | p |
|---|---|---|---|---|
n, (%) | 120 (100) | 84 (70) | 36 (30) | |
Hypothalamic involvement (HI)23 | 0.27 | |||
Anterior HI | 25 (21) | 18 (82) | 4 (5) | |
Anterior and posterior HI | 54 (45) | 38 (72) | 15 (13) | |
No HI | 7 (6) | 7 (100) | 0 (0) | |
n.a | 34 (28) | 21 (18) | 11 (10) | |
Hypothalamic lesion (HL)23 | ||||
Anterior HL | 32 (27) | 21 (70) | 9 (30) | 0.24 |
Anterior and posterior HL | 26 (22) | 19 (73) | 7 (27) | |
No HL | 33 (28) | 27 (87) | 4 (13) | |
n.a | 29 (24) | 17 (59) | 10 (3) | |
Degree of surgical resection | ||||
Complete resection | 25 (21) | 13 (52) | 11 (44) | 0.02 |
Incomplete resection | 95 (79) | 71 (75) | 19 (20) | |
Irradiation (XRT) | 61 (51) | 45 (78) | 13 (22) | 0.40 |
Photon irradiation | 36 (59) | 26 (76) | 8 (23) | |
Proton beam therapy | 20 (33) | 14 (74) | 5 (26) | |
Other XRT techniques | 4 (7) | 4 (100) | 0 (0) | |
BMI SDS22 at diagnosis | ||||
Underweight (< − 2 BMI SDS) | 5 (4) | 1 (25) | 3 (75) | 0.15 |
Normal weight (− 2 to + 2 BMI SDS) | 75 (64) | 52 (74) | 18 (26) | |
Obesity (+ 2 to + 8 BMI SDS) | 35 (30) | 27 (77) | 8 (23) | |
Severe obesity (> + 8 BMI SDS) | 3 (2) | 2 (67) | 1 (33) | |
n. a | 2 (2) | 2 (100) | 0 (0) | |
Visual impairment three months after dgx | 61 (51) | 57 (93) | 3(5) | < 0.001 |
n.a | 20 (17) | 13 (16) | 4 (13) | |
Visual impairment one year after dgx | 65 (54) | 57 (92) | 5 (8) | < 0.001 |
n.a | 14 (12) | 10 (12) | 3 (10) | |
Visual impairment three years after dgx | 54 (45) | 49 (94) | 3 (6) | < 0.001 |
n.a | 20 (17) | 15 (18) | 4 (13) |
