Figure 3 | Scientific Reports

Figure 3

From: Structural flexibility of apolipoprotein E-derived arginine-rich peptides improves their cell penetration capability

Figure 3

Cell membrane penetration of peptides. (a) Representative confocal fluorescent images of HeLa cells treated with 1 μM of FAM-labeled A2-17, StpA2-17, or StchA2-17 for 30 min at 4 °C. FAM fluorescence (green) and Hoechst fluorescence (blue) of counterstained nuclei are shown in the merge images (labelled as Merge in the photo) along with the FAM fluorescence images (labelled as FAM in the photo). The scale bars represent 20 μm. (b) Quantification of the FAM fluorescence intensity attributable to the peptide remaining in the nucleus region of cells. ****p < 0.0001; ns: not significant.

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