Figure 5
Peptide-induced membrane perturbation. (a) AFM images of LUVs in the absence (control) and presence of A2-17, StpA2-17, or StchA2-17. Scale bars represent 200 nm. (b) Membrane perturbations as defined by the rate of decrease in the stiffness of lipid vesicles. The table below the graph shows the crosslinking numbers (Crosslinking: stapled = 1; stitched = 2), α-helical contents bound to the LUVs from Fig. 1b (Helicity), and relative retention times (Hydrophobicity). ****p < 0.0001; ns: not significant.
