Table 3 Mendelian randomization estimates between muscle weakness and outcomes after excluding outliers detected by MR-PRESSO.
From: Causal influence of muscle weakness on cardiometabolic diseases and osteoporosis
Outcomes | Estimate | SE | 95% CI | P-value |
|---|---|---|---|---|
Heart failure excluding 2 outliers (rs13107325, rs10952289) | − 0.149 | 0.047 | −0. 241, −0. 056 | 0.002 |
Atrial fibrillation excluding one outlier (rs143384) | − 0.041 | 0.053 | − 0.144, 0.063 | 0.441 |
Type 2 diabetes excluding four outliers (rs7624084, rs34415150, rs10952289, rs62102286) | 0.024 | 0.080 | − 0.131, 0.180 | 0.759 |
eBMD excluding 11 outliers (rs12140813, rs958685, rs7624084, rs13107325, rs34415150, rs10952289, rs11236213, rs34464763, rs3118903, rs8061064, rs62102286) | − 0.013 | 0.034 | − 0.079, 0.053 | 0.704 |
Fracture excluding 2 outliers (rs10952289, rs34464763) | 0.037 | 0.040 | − 0.042, 0.117 | 0.355 |
