Table 4 The combined evaluation of three immunostainings and FISH results.

From: Novel RICTOR amplification harbouring entities: FISH validation of RICTOR amplification in tumour tissue after next-generation sequencing

Distribution of FISH results

High Rictor (Bethyl) expression

High Rictor (Cell Signaling) expression

High Rictor (Bethyl and/or Cell Signaling) expression

High Phospho-Ser473-Akt expression

High Rictor (Bethyl and/or Cell Signaling) and/or Phospho-Ser473-Akt expression

Amplified (n = 16)

9 (56%)

7 (44%)

10 (63%)

6 (38%)

13 (81%)

7 cases with CNV 3.00–3.99 (28%)

3 (43%)

4 (57%)

4 (57%)

3 (43%)

5 (71%)

5 cases with CNV 4.00–4.99 (71%)

4 (80%)

2 (40%)

4 (80%)

2 (40%)

5 (100%)

4 cases with CNV ≥ 5.00 (80%)

2 (50%)

1 (25%)

2 (50%)

1 (25%)

3 (75%)

Non-amplified (n = 21)

5 (24%)

5 (24%)

7 (33%)

1 (5%)

7 (33%)

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