Figure 3

Histological evaluation of osteoarthritis. Histological analysis of the paw tissues was carried out at the end of the experiment. (A) Representative Hematoxylin and Eosin (H&E) and Safranin O/Fast Green-stained sections of the right knee joint of controls and NaCl, alendronate conjugate-hyaluronic acid (ALN-HA), and HA injected rats. Magnification 100×. (B) OARSI score and (C) proteoglycan score. Results are presented as mean ± SD of 11 rats per group. * < p0.05, **p < 0.01, ***p < 0.001.