Table 1 Results of trabecular and cortical micro-CT parameters measured in sham and treated knee joints with NaCl, ALN-HA, or HA at 12 weeks after DMM surgery.

From: Effect of intra-articular injection of a hyaluronic acid-alendronate conjugate on post-traumatic osteoarthritis induced by destabilization of the medial meniscus in rats

 

SHAM

NaCl

ALN-HA

HA

Trabecular

BV (%)

55.30 ± 6.12

45.64 ± 9.08*

50.92 ± 8.07

48.74 ± 6.26

Thickness (μm)

156.01 ± 10.22

145.86 ± 9.15

154.75 ± 8.92

149.12 ± 8.50

Separation (μm)

209.04 ± 31.51

251.78 ± 35.43*

230.57 ± 42.94

226.52 ± 28.64

BMD (mg/mm3)

0.69 ± 0.07

0.64 ± 0.06

0.64 ± 0.07

0.66 ± 0.08

Cortical

Thickness (μm)

281.47 ± 16.53

257.23 ± 25.20*

274.80 ± 24.29

267.83 ± 18.85

BMD (mg/mm3)

0.97 ± 0.01

0.94 ± 0.01***

0.95 ± 0.02*

0.94 ± 0.01**

  1. *p < 0.05, **p < 0.01, ***p < 0.001 vs sham group.
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