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Figure 1

From: Aptamer-based gold nanoparticle aggregates for ultrasensitive amplification-free detection of PSMA

Figure 1

(a) Schematic representation of the sensor mechanism of action. (b) Docking modelling of the aPSMA ssDNA with the extracellular domain of the PSMA human protein. (c) Potential energy contribution of each nucleotide in the aPSMA aptamer sequence to the overall binding energy of the aptamer-PSMA complex. For further information on the energy calculation in silico, see methods section. (d) Secondary structures of the aPSMA:Rev1:Rev2 annealed sequences at 37 °C as predicted in silico by NUPACK.

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