Table 1 Significant MR estimates of the causal association between PA/SBs on OA and total joint arthroplasty.

From: Causal effect of physical activity and sedentary behaviors on the risk of osteoarthritis: a univariate and multivariate Mendelian randomization study

Exposure

Outcome

Nsnp

IVW

Weighted median

MR Egger

OR (95CI)

P value

q value

OR (95CI)

P value

OR (95CI)

P value

Light DIY

Overall OA

12

0.319 (0.158–0.646)

0.001

0.011

0.377 (0.156–0.906)

0.029

0.237 (0.021–2.654)

0.261

Light DIY

Knee OA

12

0.258 (0.116–0.570)

8.18 × 10–4

0.008

0.288 (0.096–0.861)

0.025

0.785 (0.042–14.528)

0.874

Walking for pleasure

Overall OA

20

0.869 (0.702–1.042)

0.003

0.016

0.872 (0.730–1.049)

0.469

1.061 (0.761–1.480)

0.736

Television watching

Overall OA

151

1.988 (1.637–2.413)

3.60 × 10–12

1.44 × 10–10

1.937 (1.476–2.543)

1.90 × 10–6

4.924 (2.041–11.879)

5.19 × 10–4

Television watching

Knee OA

151

1.637 (1.396–1.920)

1.33 × 10–9

2.66 × 10–8

1.580 (1.334–1.872)

1.18 × 10–6

2.616 (1.255–5.450)

0.012

Television watching

Hip OA

151

1.318 (1.110–1.565)

0.001

0.011

1.199 (0.973–1.478)

0.036

1.167 (0.527–2.584)

0.703

Television watching

TKA

147

1.104 (1.001–1.207)

0.004

0.021

1.102 (0.998–1.207)

0.179

1.012 (0.991–1.028)

0.279

  1. MR Mendelian randomization, OA osteoarthritis, TKA total knee arthroplasty, IVW inverse variance weighted, OR odds ratio, CI confidence interval; q value, FDR-adjusted P value.
Back to article page