Figure 3 | Scientific Reports

Figure 3

From: Tripartite motif 31 drives gastric cancer cell proliferation and invasion through activating the Wnt/β-catenin pathway by regulating Axin1 protein stability

Figure 3

TRIM31 depletion attenuates the proliferative and invasive capacities of GC cells. (A) The mRNA expression of TRIM31 decreased upon TRIM31 knockdown in GC cells as determined by qRT-PCR assays. (B,C) OD values were detected by CCK-8 assays upon TRIM31 knockdown in HGC-27 and BGC823 cells. (D,E) Representative images of HGC-27 and BGC823 cells from colony-formation assays. Colony data are pictured in the bar graph. (F,G) Representative photographs and quantification of GC cells as indicated in transwell experiments (magnification, × 200). (H,I) The migration rate of GC cells upon TRIM31 knockdown detected by wound-healing assays (one‐way ANOVA or t-test, *P < 0.05 and **P < 0.01, respectively).

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