Figure 5 | Scientific Reports

Figure 5

From: KTt-45, a T-type calcium channel blocker, acts as an anticancer agent by inducing apoptosis on HeLa cervical cancer cell line

Figure 5

The caspase-9 activation in HeLa cells induced by KTt-45. (A) The cleaved-caspase-9 signals of KTt-45-treated cells (37.4 μM) compared with doxorubicin treated (3 μM) and control untreated cells (0.1% (v/v) DMSO) at 48 h. (B) The cleaved-caspase-9 signals of KTt-45-treated cells (37.4 μM) compared with doxorubicin treated (3 μM) and control untreated cells (0.1% (v/v) DMSO) at 58 h. Columns (1), (2), (3), and (4) display images of cells (bright field), cell nuclei (blue field), activated caspase-9 (green field), and merging (blue and green field), respectively. The red arrows point vacuole-containing cells. The yellow arrows point shrunken cells. The scale bars indicate 50 μm.

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