Table 1 The IC50 and SI values of KTt-45 on cell lines.

From: KTt-45, a T-type calcium channel blocker, acts as an anticancer agent by inducing apoptosis on HeLa cervical cancer cell line

Cell line

IC50 (μM)

Selectivity index (SI) of KTt-45

KTt-45

DOX

A549

73.8 ± 10.4

5.9 ± 3.4

 > 1.4

HeLa

37.4 ± 8.6

0.45 ± 0.05

 > 3.2

MCF-7

73.2 ± 10.9

2.9 ± 2.2

 > 1.5

Raji

56.0 ± 8.4

0.3 ± 0.07

 > 2.6

BJ-5ta

 > 120

3.0 ± 1.2

 
  1. The values display mean ± SD (A549, MCF7, BJ-5ta, n = 3; HeLa, Raji, n = 4). DOX doxorubicin.
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