Figure 2 | Scientific Reports

Figure 2

From: Differential spatial distribution of HNF4α isoforms during dysplastic progression of intraductal papillary mucinous neoplasms of the pancreas

Figure 2

Loss of HNF4α nuclear expression isoforms in poorly differentiated invasive IPMN. (a) Average nuclear staining intensity of invasive carcinoma ROIs associated with IPMNs, as graded by 2 pathologists for pan-promoter, P1, and P2 HNF4α isoforms. The scale bar represents 100 µm. (b) Average nuclear intensity according to differentiation of invasive carcinoma component. Pan-promoter well-diff INV versus poorly diff INV: p < 0.0001; P1 well-diff INV versus poorly diff INV: p = 0.0066; P2 well-diff INV versus poorly diff INV: p = 0.0001.

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