Table 1 Genetic diversity and natural selection of global pfeba-175 RII.

From: Genetic polymorphism and natural selection of the erythrocyte binding antigen 175 region II in Plasmodium falciparum populations from Myanmar and Vietnam

Country

n

K

S

Eta

H

Hd ± SD

π ± SD

dN–dS

Tajima’s D (P value)

Fu & Li’s D (P value)

Fu & Li’s F (P value)

Vietnam

59

3.13

8

8

5

0.668 ± 0.037

0.00215 ± 0.00016

0.003

2.16677 (P < 0.05)

1.29151 (P > 0.10)

1.85964 (P < 0.05)

Myanmar

33

6.51

19

21

22

0.949 ± 0.027

0.00449 ± 0.00028

0.005

0.88890 (P > 0.10)

1.34436 (0.05 < P < 0.10)

1.40983 (P > 0.10)

Thailand

48

6.48

17

18

18

0.900 ± 0.024

0.00447 ± 0.00018

0.004

1.89489 (0.05 < P < 0.05)

1.24567 (P > 0.10)

1.73796 (P < 0.05)

Nigeria

16

6.33

15

16

16

1.000 ± 0.022

0.00437 ± 0.00041

0.005

1.23596 (P > 0.10)

0.93001 (P > 0.10)

1.16968 (P > 0.10)

Kenya

39

5.61

16

17

22

0.903 ± 0.037

0.00387 ± 0.00026

0.005

1.29041 (P > 0.10)

1.21530 (P > 0.10)

1.46354 (0.05 < P < 0.10)

Benin

8

4.46

9

9

7

0.964 ± 0.077

0.00307 ± 0.00040

0.004

1.40165 (P > 0.10)

1.11119 (P > 0.10)

1.30516 (P > 0.10)

Madagascar

7

6.33

12

13

7

1.000 ± 0.076

0.00435 ± 0.00055

0.005

1.06017 (P > 0.10)

0.81553 (P > 0.10)

0.95645 (P > 0.10)

French Guiana

62

2.24

13

13

5

0.365 ± 0.074

0.00154 ± 0.00036

0.002

–0.55758 (P > 0.10)

0.43778 (P > 0.10)

0.11360 (P > 0.10)

Colombia

20

4.48

12

12

3

0.568 ± 0.086

0.00308 ± 0.00053

0.004

1.16929 (P > 0.10)

1.46107 (P < 0.05)

1.59649 (0.05 < P < 0.10)

Peru

30

3.92

10

10

4

0.595 ± 0.057

0.00270 ± 0.00023

0.003

1.75360 (0.05 < P < 0.10)

1.40570 (P < 0.05)

1.76928 (P < 0.05)

Venezuela

9

5.78

14

14

6

0.889 ± 0.091

0.00397 ± 0.00067

0.005

0.58393 (P > 0.10)

0.73558 (P > 0.10)

0.78221 (P > 0.10)

Total

331

6.14

22

24

79

0.931 ± 0.007

0.00424 ± 0.00008

0.005

1.65946 (P > 0.10)

1.36639 (P > 0.10)

1.79893 (P < 0.05)

  1. n number of analyzed sequences, K average number of nucleotide differences, S number of segregating sites, Eta total number of mutations, H number of haplotypes, Hd haplotype diversity, π observed average pairwise nucleotide diversity, SD standard deviation, dN rate of non–synonymous substitutions, dS rate of synonymous substitutions. P < 0.05 indicates statistically significant data.
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