Figure 4
DMI images collected on the same PDAC-implanted mouse as a function of time elapsed after a deuterated glucose injection, for the different approaches here studied. Each panel is spaced by ca. 6 min, for an experimental total of 234 min. Intensities were translated into metabolic concentrations using 2H’s natural abundance (~ 10 mM concentration prior to injection in liquid-containing spaces), together with SSFP’s signal attenuations as expected from the scanning parameters and the T1/T2 for each species. Numbers on the bottom indicate to the frames compared in Supporting Information Fig. S3. Notice the initial glucose uptake by the kidney, followed by its accumulation in the tumor before being concentrated in the bladder. Notice as well the HDO gradual signal increase over time throughout the body, as well as the prominent lactate signature at the tumor position.
