Figure 6
Time courses of various mouse cases for all imaging variants executed in this study, reporting on the integrated signal observed at the [3,3′-2H2]-lactate’s chemical shift vs time following the initial injection of deuterated glucose. These integrals were taken over similar 20 mm abdominal regions for the control and pancreatitis mice, and over ca. 10 mm diameter tumor/kidney regions in the PDAC case. Notice the clear formation and metabolic kinetic dependence arising for [3,3′-2H2]-lactate’s in the tumor, vs the baseline levels evidenced by the control mice and the pancreatitis models in all other cases.
