Table 4 Data of acyclovir transferred through modified non-everted intestinal sac (nā€‰=ā€‰3).

From: An industrial procedure for the intestinal permeability enhancement of acyclovir: in-vitro and histological evidence

Ā 

r2

Interceptā€‰Ć—ā€‰10āˆ’3

Papp (cm/s)ā€‰Ć—ā€‰10āˆ’6

Total penetration %

DAE%

Pure drug

0.999

1.3

10 (Ā±ā€‰1.84)

16.055 (Ā±ā€‰0.92)

100.000

15%span 60

0.996

2.7

20 (Ā±ā€‰1.35)

35.630 (Ā±ā€‰1.08)

221.924

20%span 60

0.994

2.7

30 (Ā±ā€‰1.66)

41.125 (Ā±ā€‰2.65)

256.151

25%span 60

0.997

8.2

20 (Ā±ā€‰2.79)

54.960 (Ā±ā€‰3.93)

342.323

  1. DAE %ā€‰=ā€‰drug absorption enhancement percent compared to the pure drug.
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