Figure 1

Plasma biomarkers accurately differentiate acute and chronic/end-stage kidney disease from healthy controls. In the upper section, t-SNE plots depict the separation between acute kidney injury (AKI) patients or chronic/end-stage (CKD/ESKD) kidney patients and healthy controls (HC). Subjects plotted in 2D following dimensionality reduction of their respective proteomes by t-SNE. Axes are dimensionless. The dimensionality reduction shows that based on plasma proteome, the two cohorts were distinct and easily separable. A) Blue dots represent AKI patients and green dots represent HC subjects. B) Plasma biomarkers distinguishing AKI patients from HC subjects in order of importance C) Pink dots represent CKD/ESKD and green dots represent HC subjects. Four CKD/ESKD patients visually resemble HC subjects (refer to Supplementary Table 6). D) Plasma biomarkers distinguishing CKD/ESRD patients from HC subjects in order of importance.