Table 2 3CLpro enzyme Inhibition by RetroMAD1.

From: Inhibition of SARS-CoV-2 3CL protease by the anti-viral chimeric protein RetroMAD1

Test compounds

Concentration

3CLpro inhibition (%)

SD

Unpaired t test with Welch's correction, p-value

GC376

500 μM

101.35

1.08

 NA

RetroMAD1

33.55 μg/mL

28.35

1.60

 < 0.0001*

41.94 μg/mL

22.29

19.65

0.0197*

52.43 μg/mL

24.48

6.75

0.0021*

65.54 μg/mL

28.79

4.14

0.0006*

81.92 μg/mL

51.29

5.72

0.0033*

102.4 μg/mL

91.03

1.59

0.0013*

128 μg/mL

99.63

1.47

0.1842

160 μg/mL

98.19

1.86

0.0787

200 μg/mL

101.13

1.12

0.8173

300 μg/mL

103.44

0.60

0.0581

400 μg/mL

104.30

1.47

0.0531

  1. The data presented in this study represent the mean values obtained from three biological replicates. An unpaired t-test with Welch's correction was employed to evaluate the statistical significance of differences between GC376 and RetroMAD1 at each tested concentration. Asterisks (*) indicates significant threshold of P<0.05. NA is not applicable.
  2. Bolds are concentrations of RetroMAD1 with no significant difference compared to the tested concentration of GC376.
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