Figure 8

(A) Polygenic cross-sectional (CS) variances estimated between traits in a pairwise fashion where Lipoprotein A produced the highest variance and Testosterone showed the least genetic variance. (B) Longitudinal variances (LT) variances estimated alongside the CS variances using AI-REML. LDL direct, Cholesterol, Apolipoprotein B, and Glucose had the greatest variances and Testosterone had near-zero longitudinal variance. (C) Cross-sectional polygenic heritability estimates. (D) Longitudinal polygenic heritability estimates. CS polygenic variance and heritability estimates were generally much greater than those for LT, indicating that more cross-sectional associations are expected to be identified. Further, CS polygenic variance and heritability estimates were relatively more consistent compared with those for LT.