Table 2 Number of significant (p-value < 5e-8) variants associated with cross-sectional (CS) and longitudinal (LT) biomarker traits using multiple-trait and single-trait longitudinal GWAS as well as a conventional rate of change GWAS.
From: Fast multiple-trait genome-wide association analysis for correlated longitudinal measurements
Field ID | Cluster | Biomarker trait | GAMUT1 | GALLOP2 | Conventional GWAS3 | ||
|---|---|---|---|---|---|---|---|
CS | LT | CS | LT | Rate of change | |||
30890 | 1 | Vitamin D | 11 | 0 | 10 | 0 | 1 |
30630 | Apolipoprotein A | 20 | 0 | 11 | 0 | 0 | |
30760 | HDL cholesterol | 23 | 1 | 23 | 0 | 0 | |
30660 | Direct bilirubin | 57 | 40 | 18 | 0 | 9 | |
30840 | Total bilirubin | 63 | 175 | 57 | 0 | 11 | |
30830 | SHBG | 26 | 0 | 43 | 0 | 1 | |
30850 | Testosterone | 11 | 0 | 25 | 0 | 0 | |
30740 | 2 | Glucose | 5 | 0 | 41 | 0 | 0 |
30750 | Glycated hemoglobin (HbA1c) | 8 | 0 | 14 | 2 | 0 | |
30880 | Urate | 31 | 0 | 13 | 0 | 4 | |
30710 | C-reactive protein | 24 | 0 | 1 | 0 | 0 | |
30870 | Triglycerides | 19 | 27 | 2 | 0 | 1 | |
30670 | Urea | 1 | 0 | 24 | 0 | 0 | |
30700 | Creatinine | 3 | 0 | 19 | 27 | 0 | |
30720 | Cystatin C | 20 | 1 | 3 | 0 | 0 | |
30610 | Alkaline phosphatase | 41 | 0 | 4 | 0 | 1 | |
30730 | Gamma glutamyl transferase | 14 | 2 | 20 | 1 | 0 | |
30620 | Alanine aminotransferase | 2 | 1 | 6 | 0 | 1 | |
30650 | Aspartate aminotransferase | 12 | 0 | 31 | 0 | 1 | |
30860 | 3 | Total protein | 5 | 0 | 4 | 0 | 0 |
30600 | Albumin | 2 | 0 | 5 | 0 | 0 | |
30680 | Calcium | 4 | 0 | 2 | 0 | 0 | |
30770 | 4 | IGF-1 | 6 | 0 | 49 | 0 | 0 |
30810 | Phosphate | 3 | 0 | 27 | 0 | 1 | |
30790 | Lipoprotein A | 50 | 0 | 34 | 0 | 1 | |
30690 | Cholesterol | 17 | 0 | 3 | 0 | 1 | |
30640 | Apolipoprotein B | 35 | 1 | 6 | 0 | 3 | |
30780 | LDL direct | 26 | 0 | 18 | 0 | 1 | |
Total significant associations | 539 | 248 | 513 | 30 | 37 | ||
