Figure 4 | Scientific Reports

Figure 4

From: Hypobaric hypoxia induces iron mobilization from liver and spleen and increases serum iron via activation of ghrelin/GHSR1a/MAPK signalling pathway in mice

Figure 4

HH exposure induced a reduction in Ft-L protein expression and iron content in the liver and spleen of mice. (A,K) Expression of Ft-L protein in the liver and spleen of mice after HH exposure for 12 h, 3 d and 7 d; (B,L) Relative protein expression levels of Ft-L protein expression in panels (A) and (K); (C,G) IHC images of Ft-L in the liver and (M,Q) spleen of mice after HH exposure for 3 d and 7 d; (D,N,H,R) Semiquantitative analysis of Ft-L protein expression in panels (C) and (G), (M) and (Q); (E,O,I,S) Iron staining and tissue iron content in the liver and spleen of mice exposed to HH for 3 and 7 days. Values are displayed as the mean ± SEM (n = 6 mice), * P < 0.05, ** P < 0.01, *** P < 0.001 versus NN or indicated group.

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